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Informatics Report Series
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| Title:Modelling the influence of RKIP on the ERK signalling pathway using stochastic process algebra PEPA |
| Authors:
Muffy Calder
; Stephen Gilmore
; Jane Hillston
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| Date: 2006 |
| Publication Title:Transactions on Computational Systems Biology VII |
| Publisher:Springer-Verlag |
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Publication Type:Journal Article
Publication Status:Published
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Volume No:4230/2006
Page Nos:1-23
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DOI:10.1007/11905455_1
ISBN/ISSN:1611-3349
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- Abstract:
- This paper examines the influence of the RAF Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) singalling pathway through modelling in a Morkovian process algebra, PEPA. Two models of the system are presented, a readgent-centric view and a pathway-centric view. The models capture functionality at the level of subpathway, rather than at a molecular level. Each model affords a different perspective of the pathway and analysis. We domonstrate the two models to be formally equivalent using the timing-aware bisimulation defined over PEPA models and discuss the biological significance.
- Links To Paper
- No links available
- Bibtex format
- @Article{EDI-INF-RR-1205,
- author = {
Muffy Calder
and Stephen Gilmore
and Jane Hillston
},
- title = {Modelling the influence of RKIP on the ERK signalling pathway using stochastic process algebra PEPA},
- journal = {Transactions on Computational Systems Biology VII},
- publisher = {Springer-Verlag},
- year = 2006,
- volume = {4230/2006},
- pages = {1-23},
- doi = {10.1007/11905455_1},
- }
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