Informatics Report Series


Report   

EDI-INF-RR-1038


Related Pages

Report (by Number) Index
Report (by Date) Index
Author Index
Institute Index

Home
Title:Speeding disease gene discovery by sequence based candidate prioritization.
Authors: Euan Adie ; Richard Adams ; Kathy Evans ; David Porteous
Date:Mar 2005
Publication Title:BMC Bioinformatics
Publisher:BioMedCentral
Publication Type:Internet Publication Publication Status:Published
Volume No:6 Page Nos:55-68
DOI:10.1186/1471-2105-6-55 ISBN/ISSN:1471-2105
Abstract:
Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is reduced by matching functional annotation to knowledge of the disease or phenotype in question. However, here we show that disease genes share patterns of sequence-based features that can provide a good basis for automatic prioritization of candidates by machine learning. RESULTS: We examined a variety of sequence-based features and found that for many of them there are significant differences between the sets of genes known to be involved in human hereditary disease and those not known to be involved in disease. We have created an automatic classifier called PROSPECTR based on those features using the alternating decision tree algorithm which ranks genes in the order of likelihood of involvement in disease. On average, PROSPECTR enriches lists for disease genes two-fold 77% of the time, five-fold 37% of the time and twenty-fold 11% of the time. CONCLUSION: PROSPECTR is a simple and effective way to identify genes involved in Mendelian and oligogenic disorders. It performs markedly better than the single existing sequence-based classifier on novel data. PROSPECTR could save investigators looking at large regions of interest time and effort by prioritizing positional candidate genes for mutation detection and case-control association studies.
Links To Paper
online version of article at biomedcentral website
Final published version
Bibtex format
@Misc{EDI-INF-RR-1038,
author = { Euan Adie and Richard Adams and Kathy Evans and David Porteous },
title = {Speeding disease gene discovery by sequence based candidate prioritization.},
publisher = {BioMedCentral},
year = 2005,
month = {Mar},
howpublished={Internet Publication},
volume = {6},
pages = {55-68},
doi = {10.1186/1471-2105-6-55},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15766383},
note = {BMC Bioinformatics},
}


Home : Publications : Report 

Please mail <reports@inf.ed.ac.uk> with any changes or corrections.
Unless explicitly stated otherwise, all material is copyright The University of Edinburgh