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Title:A grid-based stochastic simulation of unitary and membrane Ca2+ currents in spherical cells
Authors: Virginia Gonzalez-Velez ; Horacio Gonzalez-Velez
Date:Jun 2005
Publication Title:CBMS 2005
Publication Type:Conference Paper Publication Status:Published
Page Nos:171-176
DOI:10.1109/CBMS.2005.10 ISBN/ISSN:0769523552
We present a stochastic simulation of L-type Ca2+ current assuming thousands of calcium channels on the membrane of a spherical cell. We propose a three-state Markov model to simulate the individual contribution of each channel. Rather than using a statistical approximation, we actually consider each individual channel transitions between states and evaluate the unitary channel current. We compare this aggregated unitary contributions with simulated whole cell currents, both in response to a depolarising voltage pulse. On the computational side, we have employed a parameter-sweep, component based approach. Being embarrassingly parallel by design, we have parallelised it in a naive manner. We argue its possible extension using algorithmic skeletons. The results presented account for hours of processing time on a dedicated grid.
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Bibtex format
author = { Virginia Gonzalez-Velez and Horacio Gonzalez-Velez },
title = {A grid-based stochastic simulation of unitary and membrane Ca2+ currents in spherical cells},
book title = {CBMS 2005},
publisher = {IEEE},
year = 2005,
month = {Jun},
pages = {171-176},
doi = {10.1109/CBMS.2005.10},
url = {},

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