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Title:Organization of brain complexity-synapse proteome form and function
Authors: Andrew Pocklington ; Douglas Armstrong ; Seth GN Grant
Date:Mar 2006
Publication Title:Briefings in Functional Genomics and Proteomics
Publisher:Oxford University Press
Publication Type:Journal Article
Volume No:5(1) Page Nos:66-73
DOI:10.1093/bfgp/e11013 ISBN/ISSN:1477-4062
Proteomic study of the synapse has generated an extensive list of molecular components, revealing one of the most complex functional systems currently known to cell biology. While fundamental to neural information processing, behaviour and disease, the molecular organisation of the synapse and its relation to higher-level function has yet to be clearly understood. Neurotransmitter receptor complexes, such as the N-methyl-D-aspartate receptor complex (NRC/MASC), are major components of the synaptic proteome. We have recently completed a detailed study of MASC, its functional organisation and involvement in behaviour and disease. This pointed to simple design principles underlying synaptic organisation. Drawing together the results of proteomic and analytical study, we sketch out a model for synaptic functional organisation.
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author = { Andrew Pocklington and Douglas Armstrong and Seth GN Grant },
title = {Organization of brain complexity-synapse proteome form and function},
journal = {Briefings in Functional Genomics and Proteomics},
publisher = {Oxford University Press},
year = 2006,
month = {Mar},
volume = {5(1)},
pages = {66-73},
doi = {10.1093/bfgp/e11013},
url = {},

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