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Title:Metabolic modeling of microbial strains in silico
Authors: M.W. Covert ; C.H. Schilling ; I. Famili ; J.S. Edwards ; Igor Goryanin ; E. Selkov ; B.O. Palsson
Date:Mar 2001
Publication Title:Trends in Biochemical Sciences
Publication Type:Journal Article Publication Status:Published
Volume No:26 (3) Page Nos:179-186
DOI:10.1016/S0968-0004(00)01754-0 ISBN/ISSN:0968-0004
The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of cellular metabolic constituents, their interactions and their integrated function as a whole. The use of quantitative analysis methods to generate testable hypotheses and drive experimentation at a whole-genome level signals the advent of a systemic modeling approach to cellular and molecular biology.
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Bibtex format
author = { M.W. Covert and C.H. Schilling and I. Famili and J.S. Edwards and Igor Goryanin and E. Selkov and B.O. Palsson },
title = {Metabolic modeling of microbial strains in silico},
journal = {Trends in Biochemical Sciences},
year = 2001,
month = {Mar},
volume = {26 (3)},
pages = {179-186},
doi = {10.1016/S0968-0004(00)01754-0},
url = {},

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