Informatics Report Series



Related Pages

Report (by Number) Index
Report (by Date) Index
Author Index
Institute Index

Title:Gravitaxis in Drosophila melanogaster: A forward genetic screen.
Authors: Douglas Armstrong ; MJ Texada ; R Munjal ; Dean Baker ; KM Beckingham
Date: 2005
Publication Title:Genes, Brain and Behavior
Publication Type:Journal Article Publication Status:Published
Volume No:5(3) Page Nos:222-239
Perception of the Earth's gravitational force is essential for most forms of animal life. However little is known of the molecular mechanisms and neuronal circuitry underlying gravitational responses. A forward genetic screen using Drosophila melanogaster that provides insight into these characteristics is described here. Vertical choice mazes combined with additional behavioral assays were used to identify mutants specifically affected in gravitaxic responses. Twenty-three mutants were selected for molecular analysis. As a result, eighteen candidate genes are now implicated in the gravitaxic behavior of flies. Many of these genes have orthologs across the animal kingdom while some are more specific to Drosophila and invertebrates. One gene (yuri) located close to a known locus for gravitaxis has been the subject of more extensive analysis including confirmation by transgenic rescue.
Links To Paper
1st link
Bibtex format
author = { Douglas Armstrong and MJ Texada and R Munjal and Dean Baker and KM Beckingham },
title = {Gravitaxis in Drosophila melanogaster: A forward genetic screen.},
journal = {Genes, Brain and Behavior},
publisher = {Blackwell},
year = 2005,
volume = {5(3)},
pages = {222-239},
doi = {10.1111/j.1601-183X.2005.00154.x},
url = {},

Home : Publications : Report 

Please mail <> with any changes or corrections.
Unless explicitly stated otherwise, all material is copyright The University of Edinburgh