Informatics Report Series
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Title:Gravitaxis in Drosophila melanogaster: A forward genetic screen. |
Authors:
Douglas Armstrong
; MJ Texada
; R Munjal
; Dean Baker
; KM Beckingham
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Date: 2005 |
Publication Title:Genes, Brain and Behavior |
Publisher:Blackwell |
Publication Type:Journal Article
Publication Status:Published
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Volume No:5(3)
Page Nos:222-239
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DOI:10.1111/j.1601-183X.2005.00154.x
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- Abstract:
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Perception of the Earth's gravitational force is essential for most forms of animal life. However little is known of the molecular mechanisms and neuronal circuitry underlying gravitational responses. A forward genetic screen using Drosophila melanogaster that provides insight into these characteristics is described here. Vertical choice mazes combined with additional behavioral assays were used to identify mutants specifically affected in gravitaxic responses. Twenty-three mutants were selected for molecular analysis. As a result, eighteen candidate genes are now implicated in the gravitaxic behavior of flies. Many of these genes have orthologs across the animal kingdom while some are more specific to Drosophila and invertebrates. One gene (yuri) located close to a known locus for gravitaxis has been the subject of more extensive analysis including confirmation by transgenic rescue.
- Links To Paper
- 1st link
- Bibtex format
- @Article{EDI-INF-RR-0316,
- author = {
Douglas Armstrong
and MJ Texada
and R Munjal
and Dean Baker
and KM Beckingham
},
- title = {Gravitaxis in Drosophila melanogaster: A forward genetic screen.},
- journal = {Genes, Brain and Behavior},
- publisher = {Blackwell},
- year = 2005,
- volume = {5(3)},
- pages = {222-239},
- doi = {10.1111/j.1601-183X.2005.00154.x},
- url = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1601-183X.2005.00154.x},
- }
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