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Title:Age-dependent Homeostatic Plasticity of GABAergic Signaling in Developing Retinal Networks
Authors: Matthias Hennig ; John Grady ; James van Coppenhagen ; Evelyne Sernagor
Date:Aug 2011
Publication Title:Journal of Neuroscience
Publisher:Society for Neuroscience
Publication Type:Journal Article Publication Status:Published
Volume No:31 Page Nos:12159-1216
DOI:10.1523/​JNEUROSCI.3112-11.2011 ISBN/ISSN:0270-6474
Developing retinal ganglion cells fire in correlated spontaneous bursts, resulting in propagating waves with robust spatiotemporal features preserved across development and species. Here we investigate the effects of homeostatic adaptation on the circuits controlling retinal waves. Mouse retinal waves were recorded in vitro for up to 35 h with a multielectrode array in presence of the GABAA antagonist bicuculline, allowing us to obtain a precise, time-resolved characterization of homeostatic effects in this preparation. Experiments were performed at P4 P6, when GABAA signaling is depolarizing in ganglion cells, and at P7 P10, when GABAA signaling is hyperpolarizing. At all ages, bicuculline initially increased the wave sizes and other activity metrics. At P5 P6, wave sizes decreased toward control levels within a few hours while firing remained strong, but this ability to compensate disappeared entirely from P7 onwards. This demonstrates that homeostatic control of spontaneous retinal activity maintains specific network dynamic properties in an age-dependent manner, and suggests that the underlying mechanism is linked to GABAA signaling.
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Bibtex format
author = { Matthias Hennig and John Grady and James van Coppenhagen and Evelyne Sernagor },
title = {Age-dependent Homeostatic Plasticity of GABAergic Signaling in Developing Retinal Networks},
journal = {Journal of Neuroscience},
publisher = {Society for Neuroscience},
year = 2011,
month = {Aug},
volume = {31},
pages = {12159-1216},
doi = {10.1523/​JNEUROSCI.3112-11.2011},
url = {},

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