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Title:A model of associative learning in the Mushroom Body
Authors: Darren Smith ; Jan Wessnitzer ; Barbara Webb
Date: 2008
Publication Title:Biological Cybernetics
Publication Type:Journal Article Publication Status:Published
The mushroom body is a prominent invertebrate neuropil strongly associated with learning and memory. We built a high-level computational model of this structure using simplified but realistic models of neurons and synapses, and developed a learning rule based on activity dependent pre-synaptic facilitation. We show that our model, which is consistent with mushroom body Drosophila data and incorporates Aplysia learning, is able to both acquire and later recall CS US associations. We demonstrate that a highly divergent input connectivity to the mushroom body and strong periodic inhibition both serve to improve overall learning performance.We also examine the problem of howsynaptic conductance, driven by successive training events, obtains a value appropriate for the stimulus being learnt.We employ two feedback mechanisms: one stabilises strength at an initial level appropriate for an association; another prevents strength increase for established associations.
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Bibtex format
author = { Darren Smith and Jan Wessnitzer and Barbara Webb },
title = {A model of associative learning in the Mushroom Body},
journal = {Biological Cybernetics},
publisher = {Springer},
year = 2008,
doi = {10.1007/s00422-008-0241-1},
url = {},

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