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Title:Draft sequencing and comparative genomics of Xylella fastidiosa strains reveal novel biological insights
Authors: Anamitra Bhattacharyya ; Stephanie Stilwagen ; Gary Reznik ; Helene Feil ; William S. Feil ; Iain Anderson ; Evgeny Selkov ; Axel Bernal ; Mark D'Souza ; Natalia Ivanova ; Vinayak Kapatral ; Niels Larsen ; Tamara Los ; Athanasios Lykidis ; Theresa L. Walunas ; Alexander Purcell ; Rob A. Edwards ; Trevor Hawkins ; Robert Haselkorn ; Ross Overbeek ; Nikos C. Kyrpides ; Paul F. Predki
Date:Oct 2002
Publication Title:Genome Research
Publisher:Genome Research
Publication Type:Journal Article Publication Status:Published
Volume No:12(10) Page Nos:1556-1563
Draft sequencing is a rapid and efficient method for determining the near-complete sequence of microbial genomes. Here we report a comparative analysis of one complete and two draft genome sequences of the phytopathogenic bacterium, Xylella fastidiosa, which causes serious disease in plants, including citrus, almond, and oleander. We present highlights of an in silico analysis based on a comparison of reconstructions of core biological subsystems. Cellular pathway reconstructions have been used to identify a small number of genes, which are likely to reside within the draft genomes but are not captured in the draft assembly. These represented only a small fraction of all genes and were predominantly large and small ribosomal subunit protein components. By using this approach, some of the inherent limitations of draft sequence can be significantly reduced. Despite the incomplete nature of the draft genomes, it is possible to identify several phage-related genes, which appear to be absent from the draft genomes and not the result of insufficient sequence sampling. This region may therefore identify potential host-specific functions. Based on this first functional reconstruction of a phytopathogenic microbe, we spotlight an unusual respiration machinery as a potential target for biological control. We also predicted and developed a new defined growth medium for Xylella.
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Bibtex format
author = { Anamitra Bhattacharyya and Stephanie Stilwagen and Gary Reznik and Helene Feil and William S. Feil and Iain Anderson and Evgeny Selkov and Axel Bernal and Mark D'Souza and Natalia Ivanova and Vinayak Kapatral and Niels Larsen and Tamara Los and Athanasios Lykidis and Theresa L. Walunas and Alexander Purcell and Rob A. Edwards and Trevor Hawkins and Robert Haselkorn and Ross Overbeek and Nikos C. Kyrpides and Paul F. Predki },
title = {Draft sequencing and comparative genomics of Xylella fastidiosa strains reveal novel biological insights},
journal = {Genome Research},
publisher = {Genome Research},
year = 2002,
month = {Oct},
volume = {12(10)},
pages = {1556-1563},
url = {},

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