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Title:Parallel stochastic simulation of macroscopic calcium currents
Authors: Virginia Gonzalez-Velez ; Horacio Gonzalez-Velez
Date:Jun 2007
Publication Title:Journal of Bioinformatics and Computational Biology
Publisher:World Scientific Publishing Co
Publication Type:Journal Article Publication Status:Published
Volume No:5 Page Nos:755-772
DOI:10.1142/S0219720007002679 ISBN/ISSN:0219-7200
This work introduces Macaco, a macroscopic calcium currents simulator. It provides a parameter-sweep framework which computes macroscopic Ca2+ currents from the individual aggregation of unitary currents, using a stochastic model for L-type Ca2+ channels. Macaco uses a simplified 3-state Markov model to simulate the response of each Ca2+ channel to different voltage inputs to the cell. In order to provide an accurate systematic view for the stochastic nature of the calcium channels, Macaco is composed of an experiment generator, a central simulation engine and a post-processing script component. Due to the computational complexity of the problem and the dimensions of the parameter space, the Macaco simulation engine employs a grid-enabled task farm. Having been designed as a computational biology tool, Macaco heavily borrows from the way cell physiologists conduct and report their experimental work.
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Bibtex format
author = { Virginia Gonzalez-Velez and Horacio Gonzalez-Velez },
title = {Parallel stochastic simulation of macroscopic calcium currents},
journal = {Journal of Bioinformatics and Computational Biology},
publisher = {World Scientific Publishing Co},
year = 2007,
month = {Jun},
volume = {5},
pages = {755-772},
doi = {10.1142/S0219720007002679},
url = {},

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