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Title:Electrostatic properties of promoter recognized by E. coli RNA polymerase Esigma70.
Authors: Anatoly Sorokin ; Alexander Osypov ; Timur Dzhelyadin ; Peter Beskaravainy ; Svetlana Kamzolova
Date:Apr 2006
Publication Title:Journal of Bioinformatics and Computational Biology
Publication Type:Journal Article Publication Status:Published
Volume No:4(2) Page Nos:455-467
Abstract:
A comparative analysis of electrostatic patterns for 359 sigma(70)-specific promoters and 359 nonpromoter regions on electrostatic map of Escherichia coli genome was carried out. It was found that DNA is not a uniformly charged molecule. There are some local inhomogeneities in its electrostatic profile which correlate with promoter sequences. Electrostatic patterns of promoter DNAs can be specified due to the presence of some distinctive motifs which differ for different promoter groups and may be involved as signal elements in differential recognition of various promoters by the enzyme. Some specific electrostatic elements which are responsible for modulating promoter activities due to ADP-ribosylation of RNA polymerase alpha-subunit were found in far upstream regions of T4 phage early promoters and E. coli ribosomal promoters.
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Bibtex format
@Article{EDI-INF-RR-0919,
author = { Anatoly Sorokin and Alexander Osypov and Timur Dzhelyadin and Peter Beskaravainy and Svetlana Kamzolova },
title = {Electrostatic properties of promoter recognized by E. coli RNA polymerase Esigma70.},
journal = {Journal of Bioinformatics and Computational Biology},
year = 2006,
month = {Apr},
volume = {4(2)},
pages = {455-467},
url = {http://dx.doi.org/10.1142/S0219720006002077},
}


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